08:00-09:00 Registration and refreshments

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09:00-09:10 Welcome (Tom Kurzawinski and Rakhee Chauhan)

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• An Introduction to RET and MEN2 (Chairs: Professor Rajesh Thakker, Mrs Jo Grey)

09:10-09:35  A RETrospective view of GDNF signalling (Professor Neil McDonald, Senior Group Leader, Francis Crick Institute)

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09:35-10:00  Testing for RET: indications, results, VUS (Dr Louise Izatt, Consultant in Clinical Genetics, Guy's and St Thomas's NHS Foundation Trust and King's College London)

 

10:00-10:25  Thyroid Surgery in MEN2: A Gospel according to RET? (Mr Tom Kurzawinski, Consultant Endocrine Surgeon, UCLH and GOSH)

 

10:25-10:50  RET and Oncogenesis with a focus on MEN2 Syndrome (Dr Rakhee Chauhan, Postdoctoral Research Fellow, Francis Crick Institute)

 

10:50-10:55  Session Discussion

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10:55-11:15  Networking Refreshment Break

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• RET and Hirschsprung’s Disease (Chairs: Dr Nikhil Thapar, Dr Tiffany Heanue)

11:15-11:40  Identification, treatment and genetics of Hirschsprung's Disease (Dr Robert M W Hofstra, Head of Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands)

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11:40-12:05  Structural insights into RET folding (Dr Svend Kjaer, STP Deputy, Francis Crick Institute)

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12:05-12:30  Sex differences in the roles of RET iso forms in the enteric nervous system and brain (Professor Robin Lovell-Badge / Dr Rosalyn Flower, Senior Group Leader / Laboratory Research Assistant, The Francis Crick Institute)

 

12:30-12:40  Session Discussion

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12:40-13:30  Lunchtime Networking

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• Diverse Roles of RET (Chairs: Professor Marta Korbonits, Dr Caroline Brain)

13:30-13:55  The Pituitary and RET (Professor Clara Alvarez, Santiago de Compostela, Spain)

 

13:55-14:20  Parkin regulates RET protein levels (Dr Edgar Kramer, Group Leader, University of Plymouth)

 

14:20-14:45  Novel functions in RET signalling: RET and GFRAL in body weight regulation (Dr Sebastian Jorgensen, Novo Nordisk)

 

14:45-15:10  Activation of RET signalling improves haematopoietic stem cell potency and bone marrow transplantation (Dr William Grey, Postdoctoral Research Fellow, Francis Crick Institute)

 

15:10-15:35  Session Discussion

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15:35-15:55  Networking Refreshment Break

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• Targeting RET in Oncology (Chairs: Professor Hong-yu Li, Professor Ashley Grossman)

15:55-16:20  TracerX RET fusions in NSCLC (Dr Crispin Hiley, Senior Lecturer & Consultant Clinical Oncologist, UCLH)

 

16:20-16:45  RET fusion and mutation in lung cancer; translation based on pan-Japan genome screening (Dr Takashi Kohno, Chief of the Devision of Genome Biology, National Cancer Centre Research Institute, Japan)

 

16:45-17:10  Targeting RET clinically: past and present therapeutics (Dr Kate Newbold, Consultant Clinical Oncologist, The Royal Marsden Hospital, London)

 

17:10-17:35  Next generation RET inhibitors: the future is here! Blueprint BLU-667 clinical efficacy in lung cancer and medullary thyroid cancer (Dr Martin Forster, Associate Professor and Consultant in Medical Oncology, UCL Cancer Institute / UCLH)

 

17:35-17:45  Session Discussion

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17:45-17:50  Closing Remarks (Mr Tom Kurzawinski and Dr Louise Izatt)

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The event will be followed by a networking drinks reception

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CPD Accreditation with the Royal College of Physicians applied for

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[The programme may be subject to change without notice]

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